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Association of HLA-BW35 with mucocutaneous lesions in rheumatoid arthritis patients undergoing sodium aurothiomalate therapy.
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These changes were associated with a major reduction in deaths involving co-proxamol compared with the expected number of deaths (an estimated 295 fewer suicides and 349 fewer deaths including accidental poisonings), but no statistical evidence for an increase in deaths involving either other analgesics or other drugs.
In early 2005 the UK Medicines and Healthcare products Regulatory Agency announced gradual withdrawal of co-proxamol because of its adverse benefit to safety ratio, especially its use for intentional and accidental fatal poisoning.
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